Drug intelligence / Profile preview

LHNVD-202

Development stage
Preclinical
Lead developer
Longhorn Vaccines and Diagnostics
Modality
Prophylactic Vaccines → Vaccines & Immunotherapeutics, Peptide-based Cancer Vaccines → Cancer Vaccines → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

LHNVD-202 is a synthetic peptide vaccine developed by Longhorn Vaccines & Diagnostics. It is designed as a dual peptide universal vaccine candidate targeting both influenza and SARS-CoV-2 (COVID-19). The vaccine comprises unconjugated composite peptides that include epitopes from highly conserved regions of influenza virus proteins (such as hemagglutinin, neuraminidase, and matrix protein) and the RNA polymerase of SARS-CoV-2. Preclinical data suggest that LHNVD-202 induces broadly reactive and durable antibody responses against multiple strains of both viruses. The primary indications are for the prevention of COVID-19 and human influenza infection[1][2].

02

Targets

NeuraminidaseSevere acute respiratory syndrome coronavirus 2 spike glycoprotein conserved epitopesHA0 (Influenza B virus hemagglutinin)M2e (Influenza A matrix protein 2 ectodomain)

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