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licartin + sorafenib
- Development stage
- Preclinical
- Lead developer
- China Isotope & Radiation Corporation
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous (Licartin), Oral (sorafenib)
01
Overview
Licartin + sorafenib is a combination therapy used primarily in the treatment of advanced hepatocellular carcinoma (HCC). Licartin is the brand name for iodine-131 metuximab, a radiolabeled monoclonal antibody targeting CD147 (also known as HAb18G/CD147) on tumor cells. It delivers targeted radiation to liver cancer cells. Sorafenib is an oral small molecule multikinase inhibitor that targets Raf kinase and several receptor tyrosine kinases involved in tumor cell proliferation and angiogenesis, including VEGFR-1/2/3 and PDGFR-β. The combination aims to enhance antitumor efficacy by combining targeted radiotherapy with molecular inhibition of tumor growth and angiogenesis[1][5][8].
- Brand names
- Nexavar
- Other names
- 利卡汀 + 索拉菲尼Iodine-131 metuximab + sorafenib131I-metuximab + sorafenib
02
Targets
VEGFR4 (Vascular endothelial growth factor Receptor-3)PDGFRB (Platelet-derived growth factor receptor beta)BRAF (B-Raf proto-oncogene, serine/threonine kinase)KIT (c-KIT proto-oncogene receptor tyrosine kinase)BSG (Basigin)FLT3 (Fms related receptor tyrosine kinase 3)FGFR1 (Fibroblast growth factor receptor 1)RAF1 (c-Raf-1 (Y340D/Y341D))VEGFR2 (Vascular endothelial growth factor receptor 2)
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