licochalcone E

Licochalcone E is a natural retrochalcone flavonoid isolated from the roots of Glycyrrhiza species (licorice), such as Glycyrrhiza inflata and Glycyrrhiza uralensis. It exhibits a wide range of pharmacological properties, including anti-inflammatory, anti-cancer, anti-diabetic, and anti-obesity activities. Mechanistically, licochalcone E acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPARγ) and an agonist of liver X receptor beta (LXRβ), while antagonizing liver X receptor alpha (LXRα). It also activates the Nrf2/ARE antioxidant pathway and inhibits the activation of NF-κB and AP-1 by suppressing AKT and MAPK signaling pathways. In preclinical models, licochalcone E has demonstrated the ability to inhibit solid tumor growth and metastasis in breast cancer, improve insulin sensitivity, and ameliorate hepatic steatosis.

Other names

Lico-Elico E