Drug intelligence / Profile preview

licorice + lotus root powder

Development stage
Preclinical
Lead developer
Second Affiliated Hospital of Zhejiang University School of Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Licorice + lotus root powder is an investigational herbal combination therapy being developed by the Second Affiliated Hospital, School of Medicine, Zhejiang University for the treatment of *Helicobacter pylori* infection. The regimen utilizes licorice (*Glycyrrhiza glabra*), a traditional Chinese medicine that has demonstrated anti-*H. pylori* activity in both in vitro and animal studies, combined with lotus root powder. In clinical trial settings (e.g., NCT06881524), this combination is administered as an adjunct to a dual-therapy regimen consisting of vonoprazan (a potassium-competitive acid blocker) and low-dose amoxicillin. The primary goal of incorporating these natural products is to enhance the eradication rate of *H. pylori* while reducing the necessity for high-dose antibiotics, thereby mitigating associated adverse effects such as nephrotoxicity.

Other names
licorice and lotus root powder

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