Drug intelligence / Profile preview

licorice fluid extract

Development stage
Unknown
Modality
Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

Licorice fluid extract is a liquid preparation derived from the roots of the plant Glycyrrhiza glabra. It contains active compounds such as glycyrrhizin, which is responsible for many of its pharmacological effects. Traditionally used in herbal and integrative medicine, licorice fluid extract has been employed to relieve symptoms associated with gastrointestinal disorders (such as peptic ulcers, gastritis, GERD), respiratory conditions (coughs, sore throat), and skin ailments (eczema). The mechanism of action involves anti-inflammatory activity—primarily through inhibition of pro-inflammatory cytokines—and mucosal protection by increasing mucus production in the gastrointestinal tract. Licorice also exhibits antiviral and antimicrobial properties due to glycyrrhizin and other flavonoids[2][4][5][6]. Excessive or prolonged use can lead to adverse effects such as hypertension and hypokalemia due to mineralocorticoid-like activity.

Other names
licorice liquid extractGlycyrrhiza glabra fluid extractlicorice root fluid extract
02

Targets

HSD11B2 (11β-HSD2)GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)

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