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Lidan Huatan Huoxue Formula
- Development stage
- Unknown
- Lead developer
- Shanghai Sixth People’s Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Lidan Huatan Huoxue Formula is a Traditional Chinese Medicine (TCM) herbal prescription developed by the Shanghai Sixth People's Hospital, specifically within its Department of Endocrinology and Metabolism. Designed to treat metabolic syndrome and non-alcoholic fatty liver disease (NAFLD), the formula is based on TCM principles of clearing the gallbladder (Lidan), resolving phlegm (Huatan), and promoting blood circulation (Huoxue). It typically comprises a combination of medicinal herbs such as *Artemisia capillaris*, *Curcuma longa*, *Alisma plantago-aquatica*, and *Salvia miltiorrhiza*. Research indicates that the formula exerts its therapeutic effects by improving insulin sensitivity, regulating lipid metabolism, and reducing hepatic steatosis. Its mechanism of action involves the activation of metabolic regulators like AMPK and the modulation of the gut-liver axis and systemic inflammatory responses.
- Brand names
- Lidan Huatan Huoxue Decoction
- Other names
- Lidan Huatan Huoxue FangLidan Huatan Huoxue Decoction
02
Targets
NF-κBGSK3 (Glycogen synthase kinase 3 beta)HIF1A (Hypoxia-inducible factor 1-alpha)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TLR4 (Toll-like receptor 4)
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