lidocaine + clonidine

Lidocaine + clonidine is a local anesthetic combination formulation investigated for intraoral anesthesia, particularly in patients with type 2 diabetes mellitus (DMT2). It consists of 2% lidocaine, a voltage-gated sodium channel blocker, and 15 mcg/mL clonidine, an alpha-2 adrenergic receptor agonist. In this formulation, clonidine acts as a vasoconstrictor and analgesic adjuvant, serving as an alternative to epinephrine. Research conducted by the University of Belgrade suggests that this combination provides effective anesthesia for dental procedures like tooth extractions while maintaining stable cardiovascular parameters, making it a potentially safer option for patients with cardiovascular concerns or diabetes compared to traditional lidocaine-epinephrine mixtures.

Other names

L + Clidocaine plus clonidinelidocaine 2% + clonidine 15 mcg/mL