lidocaine + diphenhydramine + aluminum hydroxide + magnesium hydroxide + simethicone

This drug is a **combination mouthwash formulation** containing lidocaine (a local anesthetic), diphenhydramine (an antihistamine), aluminum hydroxide and magnesium hydroxide (antacids), and simethicone (an anti-foaming agent). It is often referred to as “magic mouthwash” or BMX mouthwash and is used primarily to treat **oral mucositis pain and discomfort** associated with cancer therapy, particularly radiotherapy and chemotherapy. The mechanism of action involves multiple targets: lidocaine blocks voltage-gated sodium channels to provide local anesthesia; diphenhydramine acts as an H1 antihistamine with local anesthetic properties; aluminum hydroxide and magnesium hydroxide neutralize oral acidity and provide mucosal coating; simethicone reduces surface tension and may help distribute the mixture and reduce foaming. The efficacy is primarily symptomatic, aiming to reduce pain and allow oral intake in patients with inflamed mucosa. These combinations are typically prepared by pharmacists and may be provided as a compounded prescription or via kits such as FIRST Mouthwash BLM[9][7][5][4][2].

Brand names

FIRST Mouthwash BLM

Other names

magic mouthwashBMX mouthwashdiphenhydramine-lidocaine-antacid mouthwash