lidocaine + epinephrine + fentanyl

This is a combination of three drugs—lidocaine, epinephrine, and fentanyl—used primarily in regional anesthesia (such as epidural or spinal anesthesia) for surgical procedures including cesarean section. - **Lidocaine** is an amide-type local anesthetic that works by blocking sodium channels (specifically the sodium channel protein type 1 subunit alpha), thereby inhibiting nerve impulse conduction and producing loss of sensation in the targeted area[4]. - **Epinephrine** acts as a vasoconstrictor by stimulating adrenergic receptors (alpha-adrenergic receptor agonist), which reduces systemic absorption of lidocaine, prolongs its effect, and decreases bleeding at the site[1][3][6]. - **Fentanyl** is a potent synthetic opioid analgesic that acts primarily on mu-opioid receptors to provide additional pain relief during procedures[7][8]. The addition of fentanyl to lidocaine/epinephrine solutions has been shown to increase the duration and quality of postoperative analgesia without significantly increasing adverse effects. This combination is commonly used in obstetric anesthesia for cesarean sections due to its efficacy in providing rapid onset sensory block with prolonged pain control[1][3][5][6].

Other names

lidocaine with epinephrine and fentanyllidocaine-epinephrine-fentanyl combination