Drug intelligence / Profile preview

lidocaine + epinephrine + tetracaine

Development stage
Phase 2
Lead developer
QuVa Pharma
Modality
Small Molecules
Administration
Topical
01

Overview

Lidocaine + epinephrine + tetracaine (commonly known as LET or L.E.T.) is a topical anesthetic formulation used primarily in emergency departments, pediatric practices, and urgent care settings. It is applied to open wounds before suturing to provide local anesthesia. LET typically consists of: - 4% lidocaine - 0.05% epinephrine (also called racepinephrine bitartrate) - 0.5% tetracaine The formulation is available as a gel or solution and is dispensed in syringes. It's applied directly to wounds using a cotton-tipped applicator with firm pressure maintained for 15-30 minutes. Lidocaine and tetracaine are topical anesthetics that block sodium ion channels involved in neuronal impulse conduction, helping to relieve pain. Epinephrine/racepinephrine controls superficial bleeding by causing vessel constriction and slows the absorption rate of the anesthetics.

Brand names
L.E.T.
Other names
LET
02

Targets

AR (Adrenergic receptors)NaV alpha (Voltage-gated sodium channel alpha subunit family)

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