Drug intelligence / Profile preview

lidocaine + indocyanine green

Development stage: Preclinical
Modality: Small Molecules
Administration: Perineural, Intrathecal

Overview

Lidocaine + indocyanine green is a combination used in medical applications where lidocaine provides local anesthetic effects and indocyanine green serves as a diagnostic agent and photothermal trigger. This combination has been studied in controlled release systems where indocyanine green can trigger the release of lidocaine upon near-infrared (NIR) exposure, extending the duration of peripheral nerve blocks. The system allows for reduced instant concentration of lidocaine to minimize cytotoxicity while providing on-demand anesthetic release through photothermal mechanisms.

Targets

NaV (Voltage-gated sodium channels)

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