Drug intelligence / Profile preview

lidocaine + morphine + paracetamol + NSAID + gabapentin

Development stage
Preclinical
Lead developer
AstraZeneca
Modality
Small Molecules
Administration
Oral, Intravenous, Epidural, Intrathecal, Topical, Transdermal, Rectal
01

Overview

This is a multi-drug combination that includes five different medications with complementary mechanisms of action for pain management: - **Lidocaine**: A local anesthetic that blocks sodium channels, preventing the generation and conduction of nerve impulses - **Morphine**: An opioid analgesic that binds to mu-opioid receptors in the central nervous system - **Paracetamol** (acetaminophen): A non-opioid analgesic that inhibits prostaglandin synthesis in the central nervous system - **NSAID** (non-steroidal anti-inflammatory drug): Reduces inflammation and pain by inhibiting cyclooxygenase enzymes - **Gabapentin**: An anticonvulsant that binds to voltage-gated calcium channels in the central nervous system This combination represents a multimodal approach to pain management, targeting different pain pathways simultaneously. The combination of lidocaine and morphine has been studied for pain management, though research suggests their combination may not always provide enhanced analgesia compared to lidocaine alone in certain applications.

02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)MOR (Mu opioid receptor)PGHS-1 (Prostaglandin G/H Synthase 1)α2δ (Voltage-gated calcium channel alpha-2-delta subunit)NaV (Voltage-gated sodium channels)

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