lidocaine + nifedipine

Lidocaine + nifedipine is a fixed-dose combination drug, most commonly formulated as a topical ointment or cream, used primarily for the treatment of chronic anal fissures and related anorectal pain. Lidocaine is an amide-type local anesthetic that works by reversibly stabilizing neuronal membranes, thereby blocking the initiation and conduction of nerve impulses to provide local anesthesia. Nifedipine is a dihydropyridine calcium channel blocker that relaxes smooth muscle cells in blood vessels and the internal anal sphincter by inhibiting voltage-dependent calcium channels. This dual action results in rapid pain relief (from lidocaine) and reduced sphincter spasm with improved blood flow (from nifedipine), promoting healing of fissures. The combination has demonstrated high efficacy in clinical trials for healing chronic anal fissure, reducing resting anal pressure, relieving pain after hemorrhoidectomy, and improving patient comfort[1][4][5][6][7][8].

Brand names

NIFEDULES LDCAnoblissAnoreliefNifecaineFidonalAnosureAnofresh NLFisofineNifedipXylocaine NFLoxheal

Other names

lidocaine and nifedipine ointment