Drug intelligence / Profile preview

lidocaine + prilocaine (Verisfield)

Development stage
Phase 4
Lead developer
Verisfield
Modality
Small Molecules
Administration
Topical
01

Overview

Xylocream is a topical local anesthetic cream containing a eutectic mixture of lidocaine (2.5%) and prilocaine (2.5%). Developed and marketed by Verisfield, it is approved for inducing temporary local anesthesia (numbing) of intact skin or genital mucous membranes prior to minor medical, surgical, or aesthetic procedures (such as needle insertions, skin grafts, laser hair removal, or dermal fillers). Both active ingredients are amide-type local anesthetics that work by reversibly blocking voltage-gated sodium channels in peripheral sensory nerve fibers, thereby preventing the generation and conduction of pain signals.

Brand names
Xylocream
Other names
lidocaine and prilocainelidocaine and prilocaine creamlidocaine and prilocaine topicallidocaine/prilocainelidocaine/prilocaine creamlidocaine/prilocaine topicallignocaine and prilocainelignocaine/prilocaine
02

Targets

SCN10A (Sodium channel protein type X alpha subunit)SCN11A (NaV1.9)SCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)SCN2A (Voltage-gated sodium channel protein type 2 subunit alpha)SCN3A (Sodium channel protein type 3 subunit alpha)SCN4A (Voltage-gated sodium channel protein type 4 subunit alpha)SCN5A (Sodium channel protein type 5 subunit alpha)SCN9A (Sodium channel protein type 9 subunit alpha)

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