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Lidocaine + saline refers to the combination of the local anesthetic lidocaine and normal saline used in a clinical trial (NCT04843306) conducted by the General Hospital of Ningxia Medical University. The study evaluates the impact of combining intravenous lidocaine infusion with intraperitoneal lidocaine spray on postoperative pain in patients undergoing laparoscopic myomectomy. Lidocaine is a Class Ib antiarrhythmic and local anesthetic that works by blocking voltage-gated sodium channels, thereby preventing the conduction of pain signals. Saline is utilized both as a control and as a vehicle for the intraperitoneal administration of lidocaine. The trial aims to determine if this multimodal approach provides superior pain relief compared to standard care or single-route administration.
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