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lidocaine 10% oropharyngeal spray
- Development stage
- Phase 4
- Lead developer
- Abant Izzet Baysal University
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Lidocaine is a small molecule local anesthetic that acts as a sodium channel blocker. This specific research program by Abant Izzet Baysal University evaluated the use of a 10% topical lidocaine oropharyngeal spray (160 mg) to blunt the hemodynamic and electrocardiographic (EKG) responses—specifically QT dispersion—associated with laryngoscopy and endotracheal intubation in patients undergoing coronary artery bypass graft (CABG) surgery. By blocking sodium channels in the oropharyngeal mucosa, the drug aims to reduce the sympathetic surge and potential cardiac instability triggered by airway manipulation in patients with pre-existing coronary artery disease.
- Other names
- lidocaine 10% spraytopical lidocaineorotracheal lidocaine oral spray
02
Targets
P2RX7 (P2X purinoceptor 7)NaV (Voltage-gated sodium channels)
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