lidocaine hydrochloride + bacitracin zinc + neomycin sulfate + polymyxin b

Lidocaine hydrochloride + bacitracin zinc + neomycin sulfate + polymyxin b is an over-the-counter topical combination small-molecule drug product that combines a local anesthetic with three topical antibiotics for first-aid use on minor cuts, scrapes, and burns. Lidocaine hydrochloride provides temporary pain relief by blocking voltage-gated sodium channels in peripheral nerves, while bacitracin zinc inhibits bacterial cell wall synthesis, neomycin sulfate inhibits bacterial protein synthesis by binding the 30S ribosomal subunit, and polymyxin b disrupts the bacterial cell membrane, particularly in susceptible Gram-negative organisms. The product is marketed in ointment and cream presentations under brand names such as Neosporin Plus and related store-brand equivalents; the provided context also links the combination name to painful urethritis, but that urethritis indication more classically corresponds to lidocaine hydrochloride jelly rather than the topical four-component first-aid antibiotic combination.

Brand names

Neosporin PlusTriple Antibiotic Plus LidocaineBiotic-PlusRecelltis

Other names

lidocaine hydrochloride + bacitracin zinc + neomycin sulfate + polymyxin blidocaine hydrochloride + bacitracin zinc + neomycin sulfate + polymyxin b sulfatebacitracin zinc + neomycin sulfate + polymyxin b sulfate + lidocaine hydrochloridetriple antibiotic plus lidocaine