Drug intelligence / Profile preview

lidocaine hydrochloride + bacitracin zinc + polymyxin b sulfate + neomycin

Development stage
Unknown
Lead developer
Trifecta Pharmaceuticals
Modality
Small Molecules
Administration
Topical
01

Overview

A topical **small-molecule combination drug** comprising **lidocaine hydrochloride**, **bacitracin zinc**, **polymyxin b sulfate**, and **neomycin** for first-aid management of minor cuts, scrapes, and burns. The antibiotic components provide broad topical antibacterial coverage through complementary mechanisms: bacitracin inhibits bacterial cell wall synthesis, polymyxin B disrupts bacterial membrane integrity, and neomycin inhibits bacterial protein synthesis by binding the bacterial 30S ribosomal subunit. Lidocaine hydrochloride is a local anesthetic that blocks voltage-gated sodium channels to provide temporary relief of pain and discomfort. This is an over-the-counter topical combination product marketed in cream or ointment forms under names such as Recelltis and Triple Antibiotic Plus Lidocaine; the exact marketed product may vary by manufacturer and many OTC combinations of this type are regulated under monograph-based pathways rather than individual novel-drug approvals.

Brand names
RecelltisTriple Antibiotic Plus Lidocaine
Other names
lidocaine hydrochloride + bacitracin zinc + polymyxin b sulfate + neomycintriple antibiotic plus lidocainebacitracin zinc + polymyxin b sulfate + neomycin sulfate + lidocaine hydrochloride
02

Targets

NaV (Voltage-gated sodium channels)Bacterial RibosomeC55-PP (Undecaprenyl pyrophosphate)

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