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lidocaine-releasing intravesical system
- Development stage
- Phase 2
- Lead developer
- Taris Biomedical
- Modality
- Small Molecules
- Administration
- Intravesical
01
Overview
LiRIS (lidocaine-releasing intravesical system) is a medical device designed to deliver continuous, controlled release of lidocaine directly into the bladder over a two-week period. The device consists of a hollow, nonresorbable structure that is inserted into the bladder via the urethra and removed after treatment. Its primary mechanism is local delivery of lidocaine to relieve symptoms associated with interstitial cystitis/bladder pain syndrome (IC/BPS), including bladder pain and voiding dysfunction. Developed initially by Taris Biomedical and later acquired by Allergan and Johnson & Johnson, LiRIS was evaluated in multiple phase 2 clinical trials for IC/BPS with or without Hunner lesions but failed to demonstrate significant efficacy compared to placebo.
- Brand names
- LiRIS
- Other names
- LiRISlidocaine-releasing intravesical systemlidocaine pretzel
02
Targets
NaV (Voltage-gated sodium channels)
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