Drug intelligence / Profile preview

lifenol

Development stage
Unknown
Lead developer
Givaudan
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Lifenol is a **patented, standardized extract of female hop cones** (Humulus lupulus), rich in the phytoestrogen **8-prenylnaringenin**. It is developed as a low-dose, clinically proven dietary supplement for menopausal symptom relief and bone health. Lifenol acts by mimicking estrogenic activity, primarily attributed to prenylflavonoids such as 8-prenylnaringenin, the most potent phytoestrogen known. Randomized, double-blind, placebo-controlled clinical studies have shown that daily intake of Lifenol (85 mg) significantly reduces hot flushes, night sweats, and general menopausal discomfort, while also supporting bone mineral density in postmenopausal women. Lifenol is **100% natural, plant-based, and hormone-free**, and is well tolerated without significant side effects.

Brand names
Lifenol
Other names
hop extract8-prenylnaringenin standardized hop extract
02

Targets

ESR2 (ERβ)ESR1 (ERα)

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