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LiG-AuNPs
- Development stage
- Preclinical
- Lead developer
- University of Salerno
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intranasal
01
Overview
LiG-AuNPs (lithium-functionalized gold nanoparticles) is an innovative nanotechnology-based therapeutic formulation consisting of glutathione-stabilized gold nanoparticles loaded with lithium ions. Developed by a collaborative research effort including the University of Salerno, Università Cattolica del Sacro Cuore, and Fondazione Policlinico Universitario A. Gemelli, LiG-AuNPs are designed to act as a 'Trojan horse' for brain-specific lithium delivery. Upon intranasal administration, these nanoparticles form aggregates that are internalized by cells via endocytosis, releasing lithium ions into the cytosol through cation exchange. This targeted delivery inhibits glycogen synthase kinase 3β (GSK-3β) by increasing its inhibitory phosphorylation at Ser9, thereby reducing tau pathology and improving memory in preclinical models of Alzheimer's disease while avoiding the systemic toxicity associated with conventional oral lithium therapy.
- Other names
- a-LiG-AuNPsglutathione-stabilized gold nanoparticles loaded with lithium ionsLiG-AuNPslithium-functionalized gold nanoparticles
02
Targets
GSK3 (Glycogen synthase kinase 3 beta)
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