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Ligilactobacillus salivarius MP101
- Development stage
- Preclinical
- Lead developer
- Complutense University of Madrid
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Ligilactobacillus salivarius MP101 is a specific probiotic strain of live bacteria investigated for its immunomodulatory properties. Developed by researchers at the Universidad Complutense de Madrid, it has been studied as a supportive care intervention for COVID-19 in elderly nursing home residents. The strain is administered orally, typically via a dairy vehicle, and aims to modulate the immune microenvironment by influencing levels of pro-inflammatory cytokines and immune mediators such as IL-8, IL-31, BAFF, and TNF receptors. It is classified as a live biotherapeutic or probiotic and currently exists as a research-stage compound rather than an approved pharmaceutical drug.
- Other names
- Ligilactobacillus salivarius MP101L. salivarius MP101
02
Targets
TNFSF13 (APRIL)TNFR2 (Tumor necrosis factor receptor superfamily member 1B)SPP1 (Osteopontin)BAFF (Tumor necrosis factor ligand superfamily member 13B)TNFRSF1A (Tumor necrosis factor receptor superfamily member 1A)IL31 (IL-31)IL8 (C-X-C Motif Chemokine Ligand 8)
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