Drug intelligence / Profile preview

ligusticum + chuanxiong

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Ligusticum + chuanxiong refers to a combination of herbal ingredients derived from the rhizome of Ligusticum chuanxiong, also known as Chuanxiong or Szechwan lovage root. In traditional Chinese medicine (TCM), Ligusticum chuanxiong is one of the 50 fundamental herbs and is widely used for its ability to activate blood circulation, dissolve blood stasis, dispel wind, relieve pain, and support cardiovascular and cerebrovascular health[1][2][4][6]. The main bioactive compounds include phthalides (such as ligustilide) and alkaloids, which contribute to its anti-inflammatory, antioxidant, antithrombotic, vasodilatory, antispasmodic, analgesic (pain-relieving), immune-enhancing, anti-bacterial and anti-fungal effects[1][3][4][5]. It is commonly used in formulas for treating hematological disorders such as ischemia and thrombosis; it also supports menstrual health by nourishing blood and relieving pain associated with menstruation[1][4]. Modern research highlights its pharmacological activities in protecting against cerebral ischemia/reperfusion injury and myocardial ischemia while improving microcirculation[3][4][6].

02

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)F3 (Tissue factor)

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