limaprost

Limaprost (OP-1206) is a synthetic analog of **prostaglandin E1** with structural modifications designed for greater potency and prolonged half-life. It functions primarily as a **potent vasodilator**, increasing blood flow and inhibiting platelet aggregation. Limaprost is **orally active** and is primarily indicated to improve ischemic symptoms such as ulcer, pain, and intermittent claudication; it is also used in chronic lung disease and has shown the ability to lower pulmonary arterial pressure and vascular resistance and enhance cardiac performance. Its mechanism involves prostaglandin E receptor agonism, resulting in vasodilation, antiplatelet activity, and modulation of nerve growth factor expression in vitro. Developed and commercialized mainly in Japan, limaprost alfadex is a formulation utilizing an alpha-cyclodextrin clathrate for improved stability and delivery[1][3][4][5].

Brand names

LimaprostLimaprost alfadex

Other names

17S,20-Dimethyl-trans-delta2-PGE117α,20-dimethyl-δ2-PGE1LimaprostumLimaprostum alpha-cyclodextrin clathrateLimaprost alfadexLIMAPROSTLIMAPROST [JAN]LIMAPROST [MI]LIMAPROST [MART.]LIMAPROST [WHO-DD]Limaprostum (Latin)