LIN52 S20C

LIN52 S20C is a mutant variant of the LIN52 protein, which serves as a critical adapter subunit of the DREAM (dimerization partner, RB-like, E2F, and MuvB) complex. In high-risk Human Papillomavirus (HPV) infections, the viral E7 oncoprotein disrupts the DREAM complex by binding to the p130 protein (Retinoblastoma-like protein 2) via an LxCxE motif, thereby displacing LIN52 and promoting the expression of cell-cycle regulated genes. LIN52 S20C was engineered to have a higher affinity for the LxCxE-binding cleft of p130, allowing it to effectively compete with the HPV E7 protein for p130 binding. By restoring the assembly of the transcriptional repressor DREAM complex, LIN52 S20C suppresses the proliferation and colony-forming ability of HPV-positive cancer cells, such as HeLa and SiHa. This approach represents a potential therapeutic strategy for treating HPV-driven malignancies, including cervical and oropharyngeal carcinomas.

Other names

LIN52 mutant S20CLIN-52 mutant S20CLIN 52 mutant S20C