Drug intelligence / Profile preview

linagliptin

Development stage
Approved
Lead developer
Boehringer Ingelheim
Modality
Small Molecules
Administration
Oral
01

Overview

Linagliptin is an oral small molecule drug used to lower blood sugar levels in adults with type 2 diabetes mellitus. It belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors. Linagliptin works by inhibiting the DPP-4 enzyme, which increases concentrations of incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These hormones stimulate insulin release from pancreatic beta cells and decrease glucagon secretion from alpha cells in a glucose-dependent manner, resulting in improved regulation of blood glucose levels. Linagliptin is not indicated for type 1 diabetes or diabetic ketoacidosis. The drug was developed by Boehringer Ingelheim[1][2][5].

Brand names
TradjentaTrajenta
Other names
denagliptin
02

Targets

DPP-4 (Dipeptidyl Peptidase-IV)

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