Drug intelligence / Profile preview

Lingbao Huxin Dan

Development stage
Unknown
Lead developer
Shanghai University of Traditional Chinese Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Lingbao Huxin Dan is a traditional Chinese medicine prescription used primarily for the treatment of various cardiovascular diseases, including paroxysmal atrial fibrillation and bradycardia arrhythmia with coronary heart disease. It is a multi-component herbal formulation whose chemical composition includes bufadienolides, diterpenoids, bile acids, phenolic acids, and triterpenoid saponins. Advanced analytical studies have identified 53 volatile compounds and 191 non-volatile components in the formula. In vivo metabolism studies have revealed both phase I (hydrolysis, oxidation, hydroxylation) and phase II (glucuronidation, methylation) metabolic reactions. Mechanistic research using network pharmacology and molecular docking suggests that its therapeutic effects may involve modulation of β1-adrenergic receptor activity and L-type calcium channel function[2][3][5][6]. The product is widely recognized in China for its effectiveness in managing cardiovascular ailments but lacks standardized quality evaluation guidelines.

Brand names
Lingbao Huxin Dan
Other names
LBHX
02

Targets

CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)ADRB1 (β1)

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