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Drug intelligence / Profile preview
linifanib
- Development stage
- Phase 3
- Lead developer
- Abbott
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Linifanib is an orally active, small molecule multi-targeted receptor tyrosine kinase inhibitor. It potently inhibits all members of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor families, as well as FLT3 and KIT kinases. By blocking these pathways, linifanib suppresses tumor angiogenesis and proliferation. Linifanib was investigated in clinical trials for several solid tumors and hematologic malignancies. It was developed by Abbott Laboratories/AbbVie.
- Other names
- 1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea
02
Targets
CSF1R (Macrophage colony-stimulating factor receptor)FLT3 (Fms related receptor tyrosine kinase 3)PDGFRB (Platelet-derived growth factor receptor beta)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)KIT (c-KIT proto-oncogene receptor tyrosine kinase)
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