Drug intelligence / Profile preview

linolenic acid + polaprezinc

Development stage
Unknown
Lead developer
Zeria Pharmaceutical
Modality
Small Molecules, Peptides
Administration
Oral
01

Overview

Linolenic acid + polaprezinc is a combination of two active ingredients: linolenic acid, an essential omega-3 polyunsaturated fatty acid, and polaprezinc, a chelated complex of zinc and L-carnosine. Linolenic acid is primarily used for nutritional supplementation to address dietary deficiencies or imbalances in omega-3 fatty acids. It has demonstrated cardiovascular benefits by reducing inflammation, lowering blood pressure, improving endothelial function, and decreasing the risk of arrhythmias and thrombosis[10][8]. Polaprezinc is approved in Japan for the treatment of peptic ulcer disease and dyspepsia; it acts as a mucosal protective agent with antioxidant, anti-inflammatory, and tissue-healing properties[1][6]. The combination may be intended to provide both gastrointestinal protection (from polaprezinc) and systemic anti-inflammatory or nutritional support (from linolenic acid), though no specific branded pharmaceutical product containing both agents was identified in major regulatory databases.

02

Targets

15-LOX (Lysyl Oxidase)FADS2 (Fatty acid desaturase 2)SCD1 (Stearoyl-CoA desaturase 1)IL-6 (Interleukin 6)NF-κBPDGFRB (Platelet-derived growth factor receptor beta)TNFA (Tumor necrosis factor alpha (soluble))VEGFR-1 (Vascular endothelial growth factor receptor 1)

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