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Lip-TDM
- Development stage
- Preclinical
- Lead developer
- Kyushu University
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravesical, Intratumoral
01
Overview
Lip-TDM is an experimental immunotherapeutic agent consisting of cationic liposomes incorporating trehalose 6,6'-dimycolate (TDM), a glycolipid extracted from the cell wall of *Mycobacterium bovis* Bacillus Calmette-Guérin (BCG). It is designed as a safer, non-living alternative to intravesical BCG therapy for bladder cancer and other malignancies. Lip-TDM acts as an agonist for the Macrophage-inducible C-type lectin (Mincle) receptor, which triggers the maturation and migration of dendritic cells and subsequent activation of CD8+ T cells. In preclinical mouse models, it has demonstrated antitumor activity against bladder cancer, colon cancer, and melanoma comparable or superior to live BCG, but without the associated systemic toxicity or granuloma formation.
- Other names
- cationic liposome trehalose dimycolateliposomal trehalose 6,6'-dimycolate
02
Targets
CLEC4E (Macrophage-inducible C-type lectin receptor)
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