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lipid-lowering Chinese medicine granules
- Development stage
- Phase 4
- Lead developer
- China Academy of Chinese Medical Sciences
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Lipid-lowering Chinese medicine granules are a traditional Chinese medicine (TCM) formulation developed by the China Academy of Chinese Medical Sciences for the treatment of dyslipidemia (lipid metabolism abnormalities) in HIV-infected patients undergoing highly active antiretroviral therapy (HAART). The formulation is a multi-herb mixture consisting of Astragalus membranaceus (Huangqi), Paeonia lactiflora (Chishao), Curcuma longa (Jianghuang), Reynoutria japonica (Huzhang), Crataegus pinnatifida (Shanzha), Senna tora (Juemingzi), and Gynostemma pentaphyllum (Jiaogulan). It is designed to improve lipid profiles while maintaining the efficacy of antiviral treatments.
- Other names
- 降脂中药颗粒
02
Targets
SOAT2 (Acyl-coenzyme A:cholesterol acyltransferase 2)CYP7A1 (Cholesterol 7alpha-hydroxylase)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)LDLR (Low-density lipoprotein receptor)SREBP-2 / SREBF2 (SREBP-2)UGT1A1 (UDP-glucuronosyltransferase 1A1)miR-155-5p (MicroRNA 155-5p)
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