lipolysis-stimulated lipoprotein receptor small interfering RNA

Lipolysis-stimulated lipoprotein receptor (LSR) small interfering RNA is a preclinical RNA interference (RNAi) therapeutic designed to silence the expression of the LSR protein. LSR is a transmembrane receptor that facilitates the cellular uptake of triglyceride-rich lipoproteins and lipid-soluble antioxidants like alpha-tocopherol (vitamin E). In gynecological malignancies, including ovarian and endometrial cancers, LSR is frequently overexpressed and serves as a mechanism to evade ferroptosis by maintaining high levels of alpha-tocopherol and GPX4. Treatment with LSR siRNA has been shown in preclinical models to increase reactive oxygen species (ROS) and lipid peroxidation, leading to ferroptosis-mediated cell death and inhibition of tumor growth. This approach is being explored as a potential strategy to sensitize tumors to ferroptosis-inducing agents, particularly in the context of high-fat diet-induced tumor promotion.

Other names

LSR siRNAsiLSRLSR-KD siRNA