liposomal chlorin e6

Liposomal chlorin e6 (Ce6-LP) is an investigational nanoparticle formulation developed by Taiwan Liposome Company (TLC) for use in photodynamic therapy (PDT). It encapsulates the photosensitizer chlorin e6 within a liposomal carrier to improve its aqueous solubility and tumor-specific accumulation via the enhanced permeability and retention (EPR) effect. Upon intravenous administration and subsequent irradiation with a specific wavelength of light (typically 660 nm), the chlorin e6 molecules are excited and transfer energy to molecular oxygen, generating cytotoxic reactive oxygen species (ROS) such as singlet oxygen. These ROS cause extensive oxidative damage to cellular DNA, proteins, and lipids, and trigger apoptosis through the activation of Caspase-3. This treatment modality is being explored for the destruction of solid tumors, including hepatocellular carcinoma, as well as for the treatment of atherosclerosis. Advanced iterations of this platform may incorporate chemotherapeutic agents like platinum prodrugs to overcome tumor hypoxia and enhance therapeutic efficacy.

Other names

chlorin e6 liposomeTLC-Ce6TLC-Ce-6TLC-Ce 6