liposomal CuCQ2

**Liposomal CuCQ2** is an investigational injectable nanomedicine containing the poorly water-soluble copper(II)-clioquinol complex, Cu(CQ)2, within approximately 100 nm DSPC/cholesterol liposomes. It was developed to enable systemic delivery of copper-clioquinol, a complex formed from one copper ion and two clioquinol molecules. In preclinical mouse studies, intravenous liposomal CuCQ2 showed measurable systemic exposure and reduced growth of established U251 glioblastoma xenografts; it was also evaluated in an A2780 intraperitoneal ovarian cancer model. The proposed anticancer activity is copper-dependent and may involve disruption of tumor-cell survival signaling, including NF-kappa B signaling, but a definitive molecular target for this specific liposomal formulation has not been established. ([pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC5756275/))

Other names

liposomal Cu(CQ)2liposomal CuCQ2liposomal copper-clioquinol formulation