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Drug intelligence / Profile preview
Liposomal Cyclosporine A for Inhalation
- Development stage
- Unknown
- Lead developer
- Zambon
- Modality
- Small Molecules, Liposomes → Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Inhalation
01
Overview
Liposomal Cyclosporine A for Inhalation (L-CsA-i) is a novel liposomal formulation of the calcineurin inhibitor cyclosporine A, specifically designed for delivery to the lungs via a nebulizer. Developed by Zambon SpA (following the acquisition of Breath Therapeutics), it is intended to treat Bronchiolitis Obliterans Syndrome (BOS), a form of chronic lung allograft dysfunction in lung transplant recipients. By delivering the immunosuppressant directly to the site of disease, L-CsA-i aims to achieve high local concentrations while minimizing systemic exposure and associated toxicities. It is currently in Phase 3 clinical trials (BOSTON-1 and BOSTON-2) and has received Orphan Drug and Fast Track designations from the FDA.
- Other names
- Aerosolized liposomal cyclosporine AL-CsALiposomal Cyclosporine A
02
Targets
CN (Calcineurin)Cyp (Cyclophilin family)
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