liposomal daunorubicin

Liposomal daunorubicin is a formulation of the anthracycline antitumor antibiotic daunorubicin encapsulated in liposomes. This delivery system enhances drug accumulation at tumor sites and prolongs circulation time, resulting in higher concentrations at disease sites such as Kaposi's sarcoma lesions compared to conventional preparations[8][2]. The drug exerts its anti-cancer effects by binding to DNA and inhibiting the synthesis of proteins necessary for cell survival, leading to cancer cell death[2][5]. Liposomal encapsulation also reduces some toxicities associated with free daunorubicin. It is primarily indicated for advanced AIDS-related Kaposi's sarcoma and has been used off-label or in clinical practice for certain leukemias and lymphomas[1][8].

Brand names

DaunoXome

Other names

daunorubicin citrate liposomedaunorubicin liposomalliposomal daunorubicin citrate