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Drug intelligence / Profile preview
liposomal irinotecan + oxaliplatin + 5-fluorouracil + calcium folinate
- Development stage
- Unknown
- Lead developer
- Ipsen
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Liposomal irinotecan + oxaliplatin + 5-fluorouracil (5-FU) + calcium folinate (leucovorin) is a four-drug chemotherapy regimen primarily used as first-line treatment for metastatic pancreatic ductal adenocarcinoma. Liposomal irinotecan is a topoisomerase I inhibitor encapsulated in a lipid nanoparticle to improve delivery and reduce toxicity. Oxaliplatin is a platinum-based DNA crosslinker that induces apoptosis. 5-Fluorouracil inhibits thymidylate synthase, disrupting DNA synthesis. Calcium folinate enhances the binding of 5-FU to its target enzyme, increasing efficacy. The combination has demonstrated improved progression-free and overall survival compared to other regimens in clinical trials[1][6][8]. The regimen is also known as NALIRIFOX when using the liposomal formulation of irinotecan.
- Brand names
- Onivyde (for liposomal irinotecan)
- Other names
- nal-IRI/oxaliplatin/5-FU/LVliposomal irinotecan, oxaliplatin, fluorouracil, and leucovorinNALIRIFOX regimen
02
Targets
DNATS (Thymidylate synthase)TOP1 (DNA Topoisomerase I)
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