Drug intelligence / Profile preview

Liposomal Lactoferrin

Development stage
Unknown
Lead developer
All G
Modality
Drug Delivery Systems
Administration
Oral
01

Overview

Liposomal Lactoferrin is a formulation that utilizes advanced liposomal technology to enhance the bioavailability and effectiveness of lactoferrin, a natural iron-binding glycoprotein that belongs to the transferrin family. This white to off-white powder has a molecular weight of approximately 80 kDa and is abundantly present in mammalian exocrine fluids such as breast milk, tears, and saliva[4][8]. The mechanism of action of Liposomal Lactoferrin is multifaceted: 1. It secures iron, preventing the growth of pathogens 2. It lowers inflammation and controls immunological responses 3. It increases the function of immune cells 4. It blocks viral entry by interacting with heparan sulfate proteoglycans (HSPGs)[1][7] The liposomal encapsulation significantly enhances transport and increases the drug's efficacy against infections, inflammation, and provides immunological support[1].

02

Targets

LbpB (Lactoferrin-binding protein B)CD14 (Monocyte differentiation antigen CD14)CXCR4 (C-X-C motif chemokine receptor 4)Fe3+ (Ferric iron)HSPG (Basement membrane-specific heparan sulfate proteoglycan core protein (perlecan))ITLN1 (Intelectin-1)LRP1 (Prolow-density lipoprotein receptor-related protein 1)TLR4 (Toll-like receptor 4)

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