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liposomal long-acting injectable antibiotic for nontuberculous mycobacteria
- Development stage
- Preclinical
- Lead developer
- Akagera Medicines
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Injectable
01
Overview
A preclinical-stage liposomal long-acting injectable (LAI) antibiotic being developed by Akagera Medicines for the treatment of Non-Tuberculous Mycobacteria (NTM) infections. The formulation consists of a small molecule antibiotic encapsulated within liposomal nanoparticles. This delivery system is specifically engineered to exploit phagocytosis-mediated uptake by macrophages, the primary cellular reservoir where NTM pathogens reside and replicate. By targeting macrophages and providing a sustained-release profile, the therapy aims to enhance local drug concentrations at the site of infection while reducing systemic toxicity and improving patient compliance compared to traditional oral therapies.
- Other names
- Akagera NTM LAIAkagera liposomal antibioticliposomal long-acting injectable antibiotic for nontuberculous mycobacteria-Akagera Medicines Africa-Long-Acting Injectable (LAI)-liposomal nanoparticles-small molecule formulation-injectable-Non-Tuberculous Mycobacteria (NTMs)
02
Targets
NeuraminidaseATP Synthase
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