liposomal methotrexate

Liposomal methotrexate is a formulation of the antimetabolite drug methotrexate encapsulated within liposomes, which are lipid-based vesicles designed to improve drug delivery and reduce systemic toxicity. This formulation is primarily investigated for localized or targeted therapy, such as in the treatment of psoriasis and potentially other inflammatory or neoplastic conditions. The mechanism of action involves inhibition of dihydrofolate reductase (DHFR), leading to impaired DNA synthesis and cell proliferation, particularly in rapidly dividing cells such as cancer cells or hyperproliferative skin cells[4]. Liposomal encapsulation enhances skin penetration when used topically and may allow for more targeted delivery with reduced side effects compared to conventional systemic administration[4].

Other names

LMTXliposomal MTX