liposomal paromomycin

Liposomal paromomycin is a formulation of the aminoglycoside antibiotic paromomycin encapsulated in liposomes to enhance its delivery and efficacy, particularly for topical or localized treatment. Paromomycin acts by binding to 16S ribosomal RNA of the 30S subunit in prokaryotic ribosomes, inhibiting protein synthesis and leading to cell death. The liposomal formulation improves skin penetration and retention when used topically. Preclinical studies have shown that topical liposomal paromomycin is effective against cutaneous leishmaniasis in animal models, resulting in significant reduction of lesion size and parasite burden compared to controls[6]. The drug has also been investigated for other protozoal infections due to its broad-spectrum activity.

Other names

liposomal paromomycin sulfateLip-PM-10Lip-PM10Lip-PM 10Lip-PM-15Lip-PM15Lip-PM 15