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**Liposomal phenylephrine** is an experimental liposomal nanoparticle formulation of **phenylephrine**, a sympathomimetic vasoconstrictor and alpha-1 adrenergic receptor agonist. In published preclinical melanoma work, it was administered peri-tumorally as a sustained-release liposomal preparation to constrict local tumor vasculature, reduce washout of co-administered intratumoral chemotherapy, increase local drug dwell time, and thereby enhance antitumor activity while limiting systemic exposure. The identified evidence is preclinical and formulation-focused rather than a marketed standalone pharmaceutical product, and no specific commercial brand, code name, or established manufacturer was clearly identified.
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