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Lister strain smallpox vaccine
- Development stage
- Phase 2
- Lead developer
- Sanofi
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Percutaneous
01
Overview
The Lister strain smallpox vaccine (VV LISTER/CEP) is a second-generation, live-attenuated, replication-competent vaccine developed by Sanofi Pasteur for the prevention of smallpox (variola virus). Unlike first-generation vaccines produced in animal skin, this version is propagated in chicken embryo primary (CEP) cells to improve purity and consistency. It is administered via scarification using a bifurcated needle, inducing cross-protective anti-vaccinia antibodies. Developed primarily as a countermeasure against potential bioterrorism, the vaccine has demonstrated safety and immunogenicity profiles comparable to traditional Lister-strain vaccines in clinical trials, with studies confirming antibody persistence for at least five years post-vaccination.
- Other names
- Lister strain smallpox vaccineLister/CEPVV LISTER/CEPsecond-generation smallpox vaccine
02
Targets
C3b (Complement Component 3b)
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