lisuride

Lisuride is a small molecule ergot derivative of the ergoline family, used primarily as an antiparkinsonian agent, for migraine prophylaxis, and to treat conditions associated with high prolactin levels such as hyperprolactinaemia and acromegaly. It acts mainly as an agonist at dopamine D2 receptors and several serotonin receptors (notably 5‑HT1A, 5‑HT2A/2C), with additional antagonist activity at dopamine D1 and histamine H1 receptors. Its dopaminergic activity underlies its use in Parkinson’s disease and prolactin suppression, while serotonergic effects contribute to migraine prevention. Unlike some other ergot derivatives, lisuride does not cause psychedelic effects due to its strong 5‑HT1A agonism counteracting 5‑HT2A-mediated hallucinogenic pathways[1][2][3][6]. It is not approved in the United States but is marketed in various countries under multiple brand names.

Brand names

DoperginArolacCuvalitDipergonDopergineLysenyl ForteProlacamRevanil

Other names

LisuridaLisuridumLysuridLysuride Hydrogen MaleateMethylergol Carbamide