lithium carbonate + selective serotonin reuptake inhibitor

Lithium carbonate + selective serotonin reuptake inhibitor (SSRI) is a combination therapy used primarily in the management of mood disorders, especially bipolar disorder and treatment-resistant depression. Lithium carbonate is a classic mood stabilizer that modulates neurotransmitter activity and intracellular signaling, while SSRIs increase synaptic serotonin by inhibiting its reuptake into presynaptic neurons. This combination can be effective for patients who do not respond adequately to monotherapy with either agent. However, coadministration increases the risk of adverse effects such as neurotoxicity and serotonin syndrome, necessitating close monitoring[1][5][6][7]. The efficacy of this combination in refractory depression is supported by provisional evidence[6].