Drug intelligence / Profile preview

Lithmax

Development stage
Unknown
Lead developer
AA Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

Lithmax is a sustained-release oral tablet formulation of lithium carbonate, a small molecule mood stabilizer manufactured by AA Pharma. It is indicated for the treatment of manic episodes and as a maintenance therapy to prevent or diminish the intensity of subsequent relapses in patients with bipolar affective disorder. The therapeutic action of lithium is attributed to its ability to alter sodium transport in nerve and muscle cells, effect a shift toward the intraneuronal metabolism of catecholamines, and inhibit the intracellular formation of cyclic adenosine monophosphate (cAMP). By modulating these neurochemical pathways, Lithmax helps stabilize the mood fluctuations associated with bipolar disorder. It is currently approved and marketed in Canada as a 300 mg sustained-release formulation.

Brand names
Lithmax
Other names
lithium carbonate
02

Targets

PGM1 (Phosphoglucomutase 1)AC (Adenylyl cyclase family)GSK3 (Glycogen synthase kinase 3 beta)IMPA1 (Inositol Monophosphatase)BPNT1 (3'(2'),5'-bisphosphate nucleotidase 1)

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