Drug intelligence / Profile preview

Liuwei muxiang

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Liuwei muxiang is a traditional Tibetan medicine (Minority medicine) compound preparation composed of six herbal ingredients[4][6]. It is used for the treatment of gastric ulcer, chronic non-atrophic gastritis, and has shown potential effects in animal and cell models against colorectal cancer[2][3][5]. The main reported pharmacological actions include anti-inflammatory, antioxidant, and potential antitumor effects, mediated through regulation of the PI3K-AKT signaling pathway, modulation of immune infiltration microenvironment, inhibition of oxidative stress, and possible influence on proteins associated with cancer development (e.g., Amy2, Furin)[2][3][5]. Key active components identified include protopine, piperine, eugenol, methyl gallate, gallic acid, and costunolide[2]. The formulation is described as a light yellow to yellow powder with a fragrant smell[4]. According to available data, the herbal ingredients typically include costus root, gardenia, pomegranate, wolfsbane, cardamom, and piper longit[4].

Other names
Liuwei Muxiang powderLiuwei Muxiang pillsLWMXLWMXP
02

Targets

FurinJUN (Transcription factor Jun)CDKN1C (p57 / CDKN1C)TUBB3 (Tubulin beta-3 chain)FOS (Activator Protein 1)EPHA2 (Ephrin type-A receptor 2)

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