Drug intelligence / Profile preview

Liv.52

Development stage
Unknown
Lead developer
Himalaya Wellness Company
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Liv.52 is a widely recognized polyherbal Ayurvedic formulation developed by the Himalaya Wellness Company. First launched in 1955, it is designed to support liver health, promote hepatocellular regeneration, and protect the hepatic parenchyma from toxins, alcohol, and drug-induced hepatotoxicity. The formulation consists of a synergistic blend of several key herbal ingredients, including Capparis spinosa (Caper Bush), Cichorium intybus (Chicory), Mandura bhasma (Iron oxide), Solanum nigrum (Black Nightshade), Terminalia arjuna (Arjuna), Cassia occidentalis (Kasamarda), Achillea millefolium (Yarrow), and Tamarix gallica (Tamarisk). Liv.52 exhibits potent antioxidant, anti-inflammatory, and immunomodulatory properties, helping to restore liver enzyme levels (such as ALT and AST), reduce lipid peroxidation, and improve appetite and digestion. It is clinically used as a supportive treatment for various hepatic disorders, including alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD), viral hepatitis, and drug-induced liver injury.

Brand names
Liv.52Liv.52 DSLiv.52 DS PROLiv.52 DS SyrupLiv.52 Syrup
Other names
Himalaya Liv 52Himalaya Liv.52Himalaya Liv.52 DSHimalaya Liv.52 DS PROHimalaya Liv.52 DS SyrupHimalaya Liv.52 SyrupLiv 52Liv52Liv-52
02

Targets

AFP (Alpha-fetoprotein)PPARG (Peroxisome proliferator-activated receptor gamma)TNFA (Tumor necrosis factor alpha (soluble))MLXIPL (ChREBP / MLXIPL)

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