Drug intelligence / Profile preview

Livasupril

Development stage
Unknown
Lead developer
Hanlim Pharm. Co., Ltd.
Modality
Small Molecules
Administration
Oral
01

Overview

**Livasupril** is an oral fixed-dose lipid-lowering combination developed by Hanlim Pharm containing micronized fenofibrate 160 mg and pitavastatin calcium 2 mg. Fenofibrate is converted to fenofibric acid, a peroxisome proliferator-activated receptor alpha agonist that improves triglyceride-rich lipoprotein metabolism, while pitavastatin competitively inhibits 3-hydroxy-3-methylglutaryl-coenzyme A reductase to reduce hepatic cholesterol synthesis and increase LDL clearance. The product has been studied for mixed or complex dyslipidemia, including a completed Phase 3 trial comparing the combination with pitavastatin monotherapy. ([ichgcp.net](https://ichgcp.net/clinical-trials-registry/NCT02250976))

Brand names
Livasupril
Other names
fenofibrate + pitavastatinmicronized fenofibrate + pitavastatin calcium
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)PPARA (Peroxisome proliferator-activated receptor alpha)

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