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live attenuated herpes zoster vaccine (Shanghai Institute of Biological Products)
- Development stage
- Unknown
- Lead developer
- Shanghai Institute of Biological Products
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
This live attenuated vaccine is developed by the Shanghai Institute of Biological Products (SIBP), a subsidiary of Sinopharm, for the prevention of herpes zoster (shingles) in adults aged 40 years and older. The vaccine contains a live, weakened strain of the Varicella-Zoster Virus (VZV) at a potency of at least 4.3 LgPFU per dose. It works by boosting VZV-specific cell-mediated immunity, which typically declines with age, thereby preventing the reactivation of the latent virus in individuals who have previously had chickenpox. The vaccine has progressed through Phase 1/2 clinical trials (NCT03140358) and has advanced to Phase 3 clinical evaluation in China to assess its efficacy, safety, and immunogenicity compared to placebo and other varicella vaccines.
- Other names
- SIBP zoster vaccineinvestigational live attenuated zoster vaccinelive attenuated zoster vaccine-Shanghai Institute Of Biological Products-Herpes Zoster
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